?? ??? ????? ?????? ?? ??? ???? ????? ?????? ???????? ?????? ????? ??????? ??? ??????? ??? ??? ??????? ?? ???? ???? ?????? ??????? ?????? ??? ???? ?????? ??????? ?????? ?????? ??????? ??? ?? ??? ?????? ??????.[?]????? ??????? ?? ??? ??????? ???????? ??????? ????? ??????????:The result was loss of therapeutic response, defined as owning significantl